Chemotherapy is the most common mode of treatment for feline lymphoma. It aims to destroy the ability of cancerous cells to grow and multiply. Drugs like doxorubicin, cyclophosphamide, vincristine, and prednisone are used for chemotherapy.

The drugs are administered intravenously or by injections under the skin. The drugs will be administered over a period of several weeks. The duration of treatment depends upon the extent of disease. Most treatment regimens involve weekly treatments for two months followed by bi weekly treatment until a period of 6 months from the start of treatment. There are some side effects associated with chemotherapy in cats. This includes vomiting, diarrhea, low white blood cell count, death of healthy cells and loss of whiskers. Side effects are self limiting and usually do not require treatment.

 In case of severe side effects, the dosage of medications may be reduced. Chemotherapy has a good success rate. About 70% of the affected cats respond to treatment. In some cases, the remission period may be as long as 2 years. If the cat has been administered prednisone before, it may interfere with the success of treatment. If the cat does not respond to chemotherapy, the vet may recommend discontinuing treatment and allowing the cancer to run its course.